Albert Barnes on Acts 18:6

And when they opposed themselves. To him and his message.

And blasphemed. Acts 13:4.

He shook his raiment. As an expressive act of shaking off the guilt of their condemnation. Comp. Acts 13:45. He shook his raiment to show that he was resolved henceforward to have nothing to do with them; perhaps, also, to express the fact that God would soon shake them off, or reject them. (Doddridge.)

Your blood, etc. The guilt of your destruction is your own. You only are the cause of the destruction that is coming upon you. Mt 27:25.

I am clean. I am not to blame for your destruction. I have done my duty. The gospel had been fairly offered, and deliberately rejected; and Paul was not to blame for their ruin, which he saw was coming upon them.

I will go, etc. See Acts 13:46.

(c) "opposed themselves" 2Ti 2:25 (d) "shook his raiment" Neh 5:13 (e) "Your blood be" Eze 28:4