John Calvin on Jeremiah 48:3

By naming many cities, he shews that the whole land was doomed to ruin, so that no corner of it would be exempt from destruction. For the Moabites might have suffered some loss without much injury had they been moderately chastised; but the Prophet shews that they would be so reduced by the power of Nebuchadnezzar, that ruin would extend to every part of the land. We now then see why this catalogue of the cities is given.

By the voice of crying he means howling, a loud lamentation, heard far and wide. He says that the voice of crying would go forth from Horonaim, which some think was so called, because the city consisted of two parts, a higher and a lower part. He then adds, desolation and great destruction He thus explains himself, for the citizens of Horonaim would in vain cry out, because desolation and breaking or destruction would constrain them, that is, make them cry out so as to howl for the bitterness of their grief. It follows, —

Jeremiah 48:4

4. Moab is destroyed; her little ones have caused a cry to be heard.

4. Afflicta est Moab; audire fecerunt clamorem parvuli ejus.