Adam Clarke on Genesis 22:4

The third day - "As the number Seven," says Mr. Ainsworth, "is of especial use in Scripture because of the Sabbath day, Gen 2:2, so Three is a mystical number because of Christ's rising from the dead the third day, Mat 17:23; 1Cor 15:4; as he was crucified the third hour after noon, Mar 15:25 : and Isaac, as he was a figure of Christ, in being the only son of his father, and not spared but offered for a sacrifice, Rom 8:32, so in sundry particulars he resembled our Lord: the third day Isaac was to be offered up, so it was the third day in which Christ also was to be perfected, Luk 13:32; Isaac carried the wood for the burnt-offering, Gen 22:6, so Christ carried the tree whereon he died, Joh 19:17; the binding of Isaac, Gen 21:9, was also typical, so Christ was bound, Mat 27:2. "In the following remarkable cases this number also occurs. Moses desired to go three days' journey in the wilderness to sacrifice, Exo 5:3; and they traveled three days in it before they found water, Exo 15:22; and three days' journey the ark of the covenant went before them, to search out a resting place, Num 10:33; by the third day the people were to be ready to receive God's law, Exo 19:11; and after three days to pass over Jordan into Canaan, Jos 1:14; the third day Esther put on the apparel of the kingdom, Est 5:1; on the third day Hezekiah, being recovered from his illness, went up to the house of the Lord, 2Kgs 20:5; on the third day, the prophet said, God will raise us up and we shall live before him, Hos 6:2; and on the third day, as well as on the seventh, the unclean person was to purify himself, Num 19:12 : with many other memorable things which the Scripture speaks concerning the third day, and not without mystery. See Gen 40:12, Gen 40:13; Gen 42:17, Gen 42:18; Jon 1:17; Jos 2:16; unto which we may add a Jew's testimony in Bereshith Rabba, in a comment on this place: There are many Three Days mentioned in the Holy Scripture, of which one is the resurrection of the Messiah." - Ainsworth.

Saw the place afar off - He knew the place by seeing the cloud of glory smoking on the top of the mountain - Targum.