Adam Clarke on Jeremiah 2:37

Thou shalt go forth from him, and thine hands upon thine head - Thou shalt find all thy confidence in vain, - thy hope disappointed; - and thy state reduced to desperation. The hand being placed on the head was the evidence of deep sorrow, occasioned by utter desolation. See the case of Tamar, when ruined and abandoned by her brother Amnon, 2Sam 13:19.

Thou shalt not prosper in them - They shall all turn to thy disadvantage; and this as we shall see in the history of this people, was literally fulfilled. O what a grievous and bitter thing it is to sin against the Lord, and have him for an enemy!