Jamieson, Fausset and Brown on 2 Timothy 2:22

22. Flee--There are many lusts from which our greatest safety is in flight (Ge 39:12). Avoid occasions of sin. From the abstemious character of Timothy (1Ti 5:23) it is likely that not animal indulgences, but the impetuosity, rash self-confidence, hastiness, strife, and vainglory of young men (1Jo 2:14-16), are what he is here warned against: though the Spirit probably intended the warning to include both in its application to the Church in general.

also--Greek, "But"; in contrast to "every good work," 2Ti 2:21.

youthful--Timothy was a youth (1Ti 4:12).

righteousness--the opposite of "iniquity," that is, unrighteousness (2Ti 2:19; compare 1Ti 6:11).

peace, with, &c.--rather, put no comma, "peace with them that call on the Lord out of a pure heart" (1Ti 1:5; Ep 6:5; Col 3:22). We are to love all men, but it is not possible to be at peace with all men, for this needs community of purpose and opinion; they alone who call on the Lord sincerely (as contrasted with the false teachers who had only the form of godliness, 2Ti 3:5, 8; Tit 1:15, 16) have this community [Theodoret]. (Ro 12:18).