Jamieson, Fausset and Brown on Colossians 1:21

21. The Colossians are included in this general reconciliation (compare Ep 2:1, 12).

sometime--"once."

alienated--from God and salvation: objectively banished from God, through the barrier which God's justice interposed against your sin: subjectively estranged through the alienation of your own wills from God. The former is the prominent thought (compare Ro 5:10), as the second follows, "enemies in your mind." "Actual alienation makes habitual 'enemies'" [Bengel].

in your mind--Greek, "in your understanding" or "thought" (Ep 2:3; 4:18).

by wicked works--rather as Greek, "in your wicked works" (wicked works were the element in which your enmity subsisted).

yet now--Notwithstanding the former alienation, now that Christ has come, God hath completely reconciled, or restored to His friendship again (so the Greek, compare Note, see on Col 1:20).