Jamieson, Fausset and Brown on Daniel 2:21

21. changeth ... times ... seasons--"He herein gives a general preparatory intimation, that the dream of Nebuchadnezzar is concerning the changes and successions of kingdoms" [Jerome]. The "times" are the phases and periods of duration of empires (compare Da 7:25; 1Ch 12:32; 29:30); the "seasons" the fitting times for their culmination, decline, and fall (Ec 3:1; Ac 1:7; 1Th 5:1). The vicissitudes of states, with their times and seasons, are not regulated by chance or fate, as the heathen thought, but by God.

removed kings--(Job 12:18; Psa 75:6, 7; Jr 27:5; compare 1Sa 2:7, 8).

giveth wisdom--(1Ki 3:9-12; Jas 1:5).