Jamieson, Fausset and Brown on Isaiah 25:2

2. a city ... heap--Babylon, type of the seat of Antichrist, to be destroyed in the last days (compare Jr 51:37, with Re 18:1-24, followed, as here, by the song of the saints' thanksgiving in Re 19:1-21). "Heaps" is a graphic picture of Babylon and Nineveh as they now are.

palace--Babylon regarded, on account of its splendor, as a vast palace. But Maurer translates, "a citadel."

of strangers--foreigners, whose capital pre-eminently Babylon was, the metropolis of the pagan world. "Aliens from the commonwealth of Israel, strangers from the covenants of promise" (Is 29:5; Ep 2:12; see in contrast, Joe 3:17).

never be built--(Is 13:19, 20, &c.).