Jamieson, Fausset and Brown on Isaiah 53:3

3. rejected--"forsaken of men" [Gesenius]. "Most abject of men." Literally, "He who ceases from men," that is, is no longer regarded as a man [Hengstenberg]. (See on Is 52:14; Is 49:7).

man of sorrows--that is, whose distinguishing characteristic was sorrows.

acquainted with--familiar by constant contact with.

grief--literally, "disease"; figuratively for all kinds of calamity (Jr 6:14); leprosy especially represented this, being a direct judgment from God. It is remarkable Jesus is not mentioned as having ever suffered under sickness.

and we hid ... faces--rather, as one who causes men to hide their faces from Him (in aversion) [Maurer]. Or, "He was as an hiding of the face before it," that is, as a thing before which a man covers his face in disgust [Hengstenberg]. Or, "as one before whom is the covering of the face"; before whom one covers the face in disgust [Gesenius].

we--the prophet identifying himself with the Jews. See Horsley's view (see on Is 53:1).

esteemed ... not--negative contempt; the previous words express positive.