John Lightfoot on Matthew 8:17

[Himself took our infirmities.] Divers names of the Messias are produced by the Talmudists, among others "The Rabbins say, His name is, 'The leper of the house of Rabbi': as it is said, Certainly he bare our infirmities," &c. And a little after, "Rabh saith, If Messias be among the living, Rabbenu Haccodesh is he." The Gloss is, "If Messias be of them that are now alive, certainly our holy Rabbi is he, as being one that carries infirmities," &c. R. Judah, whom they called 'the Holy,' underwent very many sicknesses (of whom, and of his sicknesses, you have the story in the Talmud, "thirteen years Rabbi laboured under the pain of the teeth," &c.); because of which there were some who were pleased to account him for the Messias; because, according to the prophets, Messias should be 'a man of sorrows': and yet they look for him coming in pomp.

This allegation of Matthew may seem somewhat unsuitable and different from the sense of the prophet: for Isaiah speaks of the Messias carrying our infirmities in himself; but Matthew speaks concerning him healing them in others: Isaiah of the diseases of the soul (see 1 Peter 2:24); Matthew of the diseases of the body. But in this sense both agree very well, that Christ's business was with our infirmities and sorrows, and he was able to manage that business: his part was to carry and bear them, and in him was strength and power to carry and bear them. In this sense, therefore, is Matthew to be understood; he healed the demoniacs and all diseased persons with his word, that that of Isaiah might be fulfilled, He it is who is able to bear and carry our sorrows and sicknesses. And so, whether you apply the words to the diseases of the mind or the body, a plain sense by an equal easiness does arise. The sense of Isaiah reacheth indeed further; namely, That Messias himself shall be a man of sorrows, &c., but not excluding that which we have mentioned, which Matthew very fitly retains, as excellently well suiting with his case.