Matthew Poole and continuators on 1 Corinthians 1:21

21 For after that, in the wisdom of God , the world by wisdom knew not God q, it pleased God by the foolishness of preaching, to save them that believe r.

Some here by the wisdom of God understand Jesus Christ, and make the sense thus. When he who is the wisdom of God came and preached to the World. Others understand the Gospel, which is so called, v. 24. & chap. 2.7. but I take the wisdom of God in this Text to signifie the wise administrations of Divine Providence in the Government of the World to his wise ends. The unregenerate part of the World would not come to a knowledge of, and an acquaintance with God, in that way whereby he chose to reveal himself in and through Jesus Christ, as to which they were hindred by their own reasonings and knowledge and apprehended skill in things, and capacity to comprehend them, it pleased God to institute the great Ordinance of preaching the Gospel, which they count foolishness; as the sacred means by which he would bring all those that give credit to the revelation of it, and receive Christ held forth in it, to eternal Life and Salvation.

Marginal references: Rom. 1.20. See Mat. 11.25. Luke 10.21.