Matthew Poole and continuators on 2 Corinthians 5:16

16 Wherefore henceforth know we no man after the flesh ; yea, though we have known Christ after the flesh, yet now henceforth know we him no more .

Words of sense in Scripture ordinarily signifie more than the act of that sense which they express; particularly this term Know, ordinarily signifieth to approve and acknowledge; and so it signifies here. We know, that is, we regard, we acknowledge no man in the discharge of our Office; we regard no man, with respect to any external fleshly consideration. Under which notion he comprehends all things not spiritual, whether carnal relations, riches, &c.

Nay, though we have known Christ after the flesh; not from any sight of him (for we read not that Paul at any time saw Christ) but Acts 9. when he saw him, not according to the flesh, but as exalted at the right hand of God: but by the hearing of the ear Paul had known Christ, as one that had lived in the flesh, and who had conversed with men for above thirty years; Yet (saith he) we know him no more, we shall neither see, nor hear him any more in the flesh; we now only know him as he hath a glorious Body; with which he sitteth at the right hand of God.

Marginal references: Matt. 12.50. Joh. 15.14. Gal. 5.6.