Matthew Poole and continuators on 2 Kings 19:21

21 This is the word that the LORD hath spoken concerning him, The virgin , the daughter of Zion hath despised thee, and laughed thee to scorn, the daughter of Jerusalem hath shaken her head at thee .

So he calls Zion, or Ierusalem; partly, because she was pure in good measure from that gross Idolatry wherewith other people were defiled, which is called Spiritual Whoredom: partly, to signifie, that God would defend her from that Rape which Sennacherib intended to commit upon her, with no less Care and Zeal, than Parents do their Virgin Daughters from those who seek to Force and Deflour them: and partly, to intimate, That as she had not yet been Forced, and taken by her Barbarous Enemies, so she should still retain her Virginity in spight of his Attempts against her.

i. e. The People of Zion; i. e. as it follows, of Ierusalem; so called Synecdochically from the Mountain, and City of Zion, which was an eminent part of it. Cities and Countries are oft called Mothers, as 2 Sam. 20. 19. and their Inhabitants Daughters; as Numb. 21. 25. Iosh. 17. 16. Iudg. 1. 27. Psal. 45. 13. and 137. 8.

Laughed at all thy proud and impotent Threatnings. This is a Gesture of Contempt and Derision: of which, see Psal. 22. 7. and 44. 13. Ier. 18. 16. Matt. 27. 39.