Matthew Poole and continuators on Acts 28:14

14 Where we found brethren, and were desired to tarry with them seven days: And so we went toward Rome.

Christians, as some think; for so they mutually called one another. But it is not so probable that any should profess Christianity so near unto Rome, and that it should be no more known, or believed in Rome. Others therefore think that the Apostle means Iews, whom he calls brethren (being, as himself, descended from Abraham): for so he calls the Iews he found at Rome (Brethren, ver. 7.) who yet called the Christians a Sect; adding, that it was every where spoken against, ver. 22.

Rome is known to be the chief City in Italy, and to have been the Empress of the World, and famous for the Church to whom St. Paul wrote his Epistle, known by its Inscription unto them.