Matthew Poole and continuators on Ezekiel 16:45

45 Thou art thy mothers daughter, that loatheth her husband and her children; and thou art the sister of thy sisters, which loathed their husbands and their children: your mother was an Hittite, and your Father an Amorite.

The Nation of the Iews.

as much for her vicious inclinations, as for thy Original derived from her, the most wicked Daughter of as wicked a Mother.

That was weary of the best husband, that, while she doted on abominable Adulterers, did most contemptuously disregard her Husband, and forsake him,

Other lewd Women have had some love for their Children, because born of them, bread by them, and resembling them; so much of the Mother was in the Children, that some Adulteresses have loved themselves in the Children, but here's a loose Woman, an unnatural Beast, that loaths her own flesh, persecuting such as are constant to the Law of God their Father, and murthering others in Sacrifice to Devils.

It runs in the blood; as the mother, so the Sisters loved, and doted on strange flesh, were as inordinate in their Affections to others, as they were in their disaffection to their own Husbands and Children.

See ver. 3. He speaks of them collectively, and as the greatest part were.