Matthew Poole and continuators on Hebrews 10:4

4 For it is not possible that the blood of bulls and of goats, should take away sins.

For, gives a reason of the precedent Proof, That the legal Sacrifices did keep Sins in Remembrance; for they were of such matter as could not have any causal Power to take them away.

This is equivalent to an Universal Negative, the Impossibility being absolute as to the things themselves in their very Nature, they being corporeal, can have no Influence upon a spiritual Evil in the Soul, Mich. 6.6, 7. and by God's Constitution they were to lead them to better things, God being not pleased with Flesh and Blood, Psalm 50.13. Isa. 1.11.

The Blood of these were only carried into the Holy of Holiest on the Atonement-day, yearly, Lev. 16. to which this is chiefly applied; nor could the Blood of all the other Sacrifices by Expiation, pardon their Offerers, nor by Sanctification cleanse them, nor by removing the sense of them, comfort the Soul; they could neither pacifie God, nor the Sinners Conscience, having no Virtue or Power to satisfie God's Justice, or merit his Grace, only it had by his Constitution a Power to type out that Blood which could do both.

Marginal references: Chap. 9.13.