Matthew Poole and continuators on Hosea 6:8

8 Gilead is a city of them that work iniquity : and is polluted with blood .

One of the six Cities of Refuge, scituate in the Country of that Name, on a high hill, whence 'tis called Ramoth Gilead, now as a City of Refuge it was a City pertaining to the Priests and Levites as all the Cities of Refuge did, in what Tribe soever they were. Numb. 35.6.

A Sacerdotal City where Priests did, and Religion; i. e. Knowledge of God, and mercy to man should dwell, but Gilead is a City full of most notorious transgressours, the Inhabitants though Levites and Priests, are a generation of men that work all manner of wickedness.

Murthers committed there have polluted it, or Murthers protected there against the Law of God, who provided these Cities a relief for such as unawares, without malice, by chance slew his Neighbour, not for wilful Murtherers; yet these for Money or Interest got in and were secured there. And probably many kept out or delivered up to the avenger of Blood contrary to the Law, thus Gilead by Name, and all the rest of the Cities of refuge intended too, were polluted with Bloud.

Marginal references: Or, cunning for blood.