Matthew Poole and continuators on Jeremiah 21:10

10 For I have set my face against this city, for evil, and not for good , saith the LORD; it shall be given into the hand of the king of Babylon, and he shall burn it with fire s.

That is, I will set my self against it, I will be an Enemy to it. See the like phrase Lev. 17.10. & 20.5. It is a phrase signifying not onely Gods aversion from them, and the taking his Affection off them, but his determination to bring ruine upon them, and chusing methods of Providence tending and conductive thereunto; and so it is opened in the following words, which are rather to be understood of the structure of the City, than of the inhabitants, for that, not the people were burnt with fire, though probably many of the people perished in so great burnings.