Matthew Poole and continuators on Jeremiah 50:3

3 For out of the north there cometh up a nation against her , which shall make her land desolate, and none shall dwell therein: they shall remove, they shall depart both man and beast .

From Media which lay Northward to Babylon and Assyria through which Cyrus his way to Babylon lay.

This Prophesie seemeth not to relate only to Cyrus his first taking of Babylon, who dealt very gently with it, but to a second taking of it by Darius the King of the Medes, who upon their defection from the Persian Monarchy, came and made an horrible devastation amongst them, hanging up (as some tell us) four thousand of their Nobles, and slaying multitudes of the common People, or of the mischief did them afterward by Seleucus Nicanor, who is said to have built a City which he called Seleucia, within fourscore, and ten miles of Babylon, by which means he brought Babylon to an utter desolation.