Matthew Poole and continuators on Job 22:5

5. Is not thy wickedness great, and thine iniquities infinite ?

Thy great sins are the true and only causes of thy misery. The words may very well be rendred thus, Is not thy evil (i. e. thy punishment or affliction, which is frequently expressed by this very word) great, because (the particle and being oft used causally, as it is Gen. 18. 13. & 22. 12. & 24. 56. Isa. 39. 1. & 64. 5.) thine Iniquities are infinite? Are not thy calamities procured by, and proportionable to thy sins? Thy own Conscience tells thee they are so. And therefore thou hast no reason to accuse God, nor any person but thy self.

Marginal references: Heb. no end to thine Iniquities.