Matthew Poole and continuators on Numbers 18:5

5 And ye shall keep the charge of the sanctuary , and the charge of the altar, that there be no wrath any more upon the children of Israel .

(i. e.) Of the holy, and of the most holy, place.

For coming too near the holy place or for usurping any part of your sacred function, or for any other miscarriage which they may be guilty of through your carelessness or remissness, in which case they shall perish for their errour▪ but their blood will I require at your hands, who should have advised them better or over-ruled them.