Matthew Poole and continuators on Revelation 12:13

13 And when the dragon saw that he was cast unto the earth , he persecuted the woman which brought forth the man child .

When the Devil saw that he could not uphold his Kingdom by Paganism, nor further execute his Malice by Pagan Emperors, but was wholly routed and overcome, as to that Power.

To let us know, that he retained his Malice, tho he had lost his former Power; he goes on in pursuing the Church of God to its ruine, only doth it in another Form; heretofore in the Form of a Pagan, now under the Pretence of a Christian; by Hereticks, the Spawn of Arrius and Photinus, (who were before this time) and by Pelagius, Nestorius, and Eutyches, who all were betwixt 400 and 500, and by Antichrist the Beast we shall read of, ch. 13.1. with seven Heads and ten Horns.