Matthew Poole and continuators on Revelation 12:17

17 And the dragon was wroth with the woman , and went to make war with the remnant of her seed , which keep the commandments of God, and have the testimony of Jesus Christ .

The Devil hath been defeated in two Designs against the whole Church; he could not wholly root it out by the Ten Persecutions under the Roman Emperors, nor by the Water thrown out of his Mouth, pestilent Doctrines which he influenced some to broach; but he was angry still, his Rage was not extinguished.

He gives over his Design to ruine the whole Church, as not practicable, but resolves to do all the Mischief he could to the Remnant of her Seed, to particular Christians;

those especially, which kept closest to the Doctrine of Faith called here the Testimony of Iesus Christ, and to the Rule of an holy Life, which is meant by keeping the Commandments of God. Hence Antichrist's Rage hath not been against Christians in general, as was the Pagans, but only against such Christians as he hath not been able to bring over to him, in a Compliance with his Corruptions in Doctrine, Worship, and Discipline.

Marginal references: 1 Cor. 2.1. 1 John 5.10.