Matthew Poole and continuators on Revelation 14:10

10 The same shall drink of the wine of the wrath of God , which is poured out without mixture, into the cup of his indignation , and he shall be tormented with fire and brimstone in the presence of his holy angels, and in the presence of the Lamb .

Those that do yield a Subjection to him, and profess his Faith, shall drink of the Wine of the Wrath of God; that is, shall feel the Severity of God's judicial Dispensations, which in Scripture are expressed by the Wine Cup of his Fury, Jer. 25.15. See also Iob 21.20. Psalm 75.8. Isa. 51.17. either from the intoxicating quality of Wine, or the stupifying quality of it, when mixed with Myrrh, or other stupifying things.

But here it is said without Mixture, which signifies their sensible feeling of the Effects of Divine Wrath.

That is, in short, he shall go to Hell at last; the exquisiteness of which Torments, as to the Pain of sense, is se[illegible: 1 letter] out by Fire and Brimst[illegible: 1 letter]ne; Brimstone being a material in which Fire holds longest to torment any Flesh put into it.

Marginal references: Chap. 18.6.; Chap. 16.19.; Chap. 20.10.; Chap. 19.20.