Charles H. Spurgeon on Psalms 107:18

Their soul abhorreth all manner of meat. Appetite departs from men when they are sick: the best of food is nauseous to them, their stomach turns against it. And they draw near unto the gates of death. From want of food, and from the destructive power of their malady, they slide gradually down till they lie at the door of the grave; neither does the skill of the physician suffice to stay their downward progress. As they cannot eat there is no support given to the system, and as the disease rages their little strength is spent in pain and misery. Thus it is with souls afflicted with a sense of sin, they cannot find comfort in the choicest promises, but turn away with loathing even from the gospel, so that they gradually decay into the grave of despair. The mercy is that though near the gates of death they are not yet inside the sepulchre.