Charles H. Spurgeon on Psalms 119:22

Remove from me reproach and contempt. Here David prays against the reproach and contempt of men; that they might be removed, or, as the word is, rolled from off him. This intimates that they lay upon him, and neither his greatness nor his goodness could secure him from being libelled and lampooned: some despised him and endeavoured to make him mean, others reproached him and endeavoured to make him odious. It has often been the lot of those that do well to be ill spoken of. It intimates, that this burden lay heavy upon him. Hard words indeed and foul words break no bones, and yet they are very grievous to a tender and ingenuous spirit: therefore David prays, Lord, "remove" them from me, that I may not be thereby either driven from any duty, or discouraged in it. Matthew Henry