Charles H. Spurgeon on Psalms 22:20

"Deliver my soul from the sword." By the sword is probably meant entire destruction, which as a man he dreaded; or perhaps he sought deliverance from the enemies around him, who were like a sharp and deadly sword to him. The Lord had said, "Awake, O sword," and now from the terror of that sword the Shepherd would fain be delivered as soon as justice should see fit. "My darling from the power of the dog." Meaning his soul, his life, which is most dear to every man. The original is, "my only one," and therefore is our soul dear, because it is our only soul. Would that all men made their souls their darlings, but many treat them as if they were not worth so much as the mire of the streets. The dog may mean Satan, that infernal Cerberus, that cursed and cursing cur; or else the whole company of Christ's foes, who though many in number were as unanimous as if there were but one, and with one consent sought to rend him in pieces. If Jesus cried for help against the dog of hell, much more may we. Cave canem, beware of the dog, for his power is great, and only God can deliver us from him. When he fawns upon us, we must not put ourselves in his power; and when he howls at us, we may remember that God holds him with a chain.