Charles H. Spurgeon on Psalms 38:3

There is no soundness in my flesh because of thine anger. Mental depression tells upon the bodily frame; it is enough to create and foster every disease, and is in itself the most painful of all diseases. Soul sickness tells upon the entire frame; it weakens the body, and then bodily weakness reacts upon the mind. One drop of divine anger sets the whole of our blood boiling with misery. Neither is there any rest in my bones because of my sin. Deeper still the malady penetrates, till the bones, the more solid parts of the system, are affected. No soundness and no rest are two sad deficiencies; yet these are both consciously gone from every awakened conscience until Jesus gives relief. God's anger is a fire that dries up the very marrow; it searches the secret parts of the belly. A man who has pain in his bones tosses to and fro in search of rest, but he finds none; he becomes worn out with agony, and in so many cases a sense of sin creates in the conscience a horrible unrest which cannot be exceeded in anguish except by hell itself.