Charles H. Spurgeon on Psalms 69:21

They gave me also gall for my meat. This was the sole refreshment cruelty had prepared for him. Others find pleasure in their food, but his taste was made to be an additional path of pain to him. And in my thirst they gave me vinegar to drink. A criminal's draught was offered to our innocent Lord, a bitter portion to our dying Master. Sorry entertainment had earth for her King and Saviour. How often have our sins filled the gall cup for our Redeemer? While we blame the Jews, let us not excuse ourselves. From this point David and our Lord for awhile part company, if we accept the rendering of our version. The severe spirit of the law breathes out imprecations, while the tender heart of Jesus offers prayers for his murderers. The whole of these verses, however, may be viewed as predictions, and then they certainly refer to our Lord, for we find portions of them quoted in that manner by the apostle in Ro 11:9-10, and by Christ himself in Mt 23:38.