John Wesley on Isaiah 53:6

We - All mankind. Astray - From God. Have turned - In general, to the way of sin, which may well be called a man's own way, because sin is natural to us, inherent in us, born with us; and in particular, to those several paths, which several men chuse, according to their different opinions, and circumstances. Hath laid - Heb. hath made to meet, as all the rivers meet in the sea. The iniquity - Not properly, for he knew no sin; but the punishment of iniquity, as that word is frequently used. That which was due for all the sins of all mankind, which must needs be so heavy a load, that if he had not been God as well as man, he must have sunk under the burden.