John Wesley on Matthew 26:37

And taking with him Peter and the two sons of Zebedee - To be witnesses of all; he began to be sorrowful and in deep anguish - Probably from feeling the arrows of the Almighty stick fast in his soul, while God laid on him the iniquities of us all. Who can tell what painful and dreadful sensations were then impressed on him by the immediate hand of God? The former word in the original properly signifies, to be penetrated with the most exquisite sorrow; the latter to be quite depressed, and almost overwhelmed with the load.